Changes in Hormonal Spectrum in Ovarian Polycystosis with Clomiphenrezistence-Binding Infertility
Abstract
This study studied the risk factors for the development of recurrent polycystic ovaries, the role of obesity in its development. For the study, 92 women with recurrent polycystic ovaries aged 19-35 years with and without obesity were studied in the control group of 20 healthy women living in the Bukhara region. The study concluded that hyperinsulinemia plays an important role in the development of the disease in patients with obesity-related OC, while dysfunction associated with the hypothalamic-pituitary system (induced by stress), on the other hand, plays an important role in the development of OCJ independently. from obesity in patients of the second group.
References
F. N. Alieva and N. V. Samburova, “Izuchenie osnovnix etiopathogeneticheskix michanov formirovaniya syndroma polycystoznix yaichnikov,” Molodezhny Nauchny Forum: Estestvennie i Medisinskie Nauki, no. 2(41), pp. 16–25, 2017.
A. E. Blesmanovich, Yu. A. Petrov, and A. G. Alexina, “Syndrome polikistoznich yaichnikov: classics i sovremennie nyuansi,” Zdorove i Obrazovanie v XXI Veke, vol. 20, no. 4, pp. 33–37, 2018.
E. R. Vedzijeva, I. V. Kuznetsova, and Yu. B. Uspenskaya, et al., “K voprosu o pathogeneze reproductivnix narusheniy u jentshin s ojireniem,” Akusherstvo i Ginekologiya, no. 6, pp. 18–25, 2017.
M. V. Glukhova, T. V. Draznina, T. V. Karpov, et al., “Osobennosti klinicheskix, hormonalnix i metabolicheskix narusheniy u bolnix s syndromom polikistoznix yaichnikov s raznimi tipami ojireniya i normalnoy massoy tela,” Upravlenie Kachestvom Meditsinskoy Pomoshchi, no. 1–2, pp. 33–37, 2016.
O. R. Grigoryan and E. N. Andreeva, “Syndrome polycystaznix yaichnikov—atdalennie riski,” Effektivnaya Farmakoterapiya, no. 5, pp. 20–25, 2015.
S. O. Dubrovina, Yu. D. Berlim, L. V. Krasilnikova, et al., “Prognozirovanie residiva endometrioidnix cyst yaichnika vo vremya pervichnogo operativnogo vmeshatelstva,” Tavrichesky Mediko-Biologichesky Vestnik, vol. 21, no. 2, pp. 26–30, 2018.
Z. S. Zaydieva and A. T. Uruymagova, “Syndrome polycystoznix yaichnikov: sovremennie predstavleniya pathogenesis, diagnostiki i lecheniya,” Medisinsky Sovet, no. 13, pp. 102–111, 2021.
N. N. Karimova, N. S. Naimova, E. M. Halimova, and D. N. Karimov, “Metodi korrektsii hormonalnogo dysbalansa u jentshin s syndromom prejdevremennoy nedostatochnosti yaichnikov,” New Day in Medicine, vol. 3(35/1), pp. 203–206, Tashkent, 2021.
S. Levine and O. Muneyyirci-Delale, “Stress-induced hyperprolactinemia: pathophysiology and clinical approach,” Obstet. Gynecol. Int., vol. 2018, article 9253083, 2018, doi: 10.1155/2018/9253083.
N. S. Naуimova and N. N. Karimova, “Disharmony and its correction in premature ovarian insufficiency,” J. Pharm. Negative Results, vol. 13 (Special Issue 08), pp. 3328–3332, 2022.
Hormones and Behavior, vol. 60, no. 3, pp. 284–291, 2011, doi: 10.1016/j.yhbeh.2011.06.003.
Y. Gao, F. Chen, Q. Q. Kong, S. F. Ning, H. J. Yuan, H. Y. Lian, M. J. Luo, and J. H. Tan, “Stresses on female mice impair oocyte developmental potential: effects of stress severity and duration on oocytes at the growing follicle stage,” Reprod. Sci., vol. 23, no. 9, pp. 1148–1157, 2016.
S. Prasad, M. Tiwari, A. N. Pandey, T. G. Shrivastav, and S. K. Chaube, “Impact of stress on oocyte quality and reproductive outcome,” J. Biomed. Sci., vol. 23, p. 36, 2016, doi: 10.1186/s12929-016-0253-4.
M. K. Gupta and S. Y. Chia, “Ovarian hormones: structure, biosynthesis, function, mechanism of action, and laboratory diagnosis,” in Clinical Reproductive Medicine and Surgery: A Practical Guide, New York: Springer, 2013, pp. 1–30.
Copyright (c) 2025 Usmanova M.S

This work is licensed under a Creative Commons Attribution 4.0 International License.
In submitting the manuscript to the Central Asian Journal of Innovations on Tourism Management and Finance, the authors certify that:
- They are authorized by their co-authors to enter into these arrangements.
- The work described has not been formally published before, except in the form of an abstract or as part of a published lecture, review, thesis, or overlay journal.
- That it is not under consideration for publication elsewhere,
- The publication has been approved by the author(s) and by responsible authorities – tacitly or explicitly – of the institutes where the work has been carried out.
- They secure the right to reproduce any material that has already been published or copyrighted elsewhere.
- They agree to the following license and copyright agreement.
License and Copyright Agreement
Authors who publish with Central Asian Journal of Innovations on Tourism Management and Finance agree to the following terms:
- Authors retain copyright and grant the Central Asian Journal of Innovations on Tourism Management and Finance right of first publication with the work simultaneously licensed under Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the Central Asian Journal of Innovations on Tourism Management and Finance published version of the work (e.g., post it to an institutional repository or edit it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) before and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.



